Advances and Applications in Statistics
Volume 57, Issue 2, Pages 105 - 119
(August 2019) http://dx.doi.org/10.17654/AS057020105 |
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MULTILEVEL MODELLING TO EXAMINE THE EFFECT OF MOTHERS’ SMOKE PRIOR TO PREGNANCY ON CHILDHOOD AND ADULTHOOD ASTHMA
Ghada Abo-Zaid
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Abstract: Objectives
The main object of this study is to examine the association between mothers’ smoke prior to pregnancy and developing asthma in childhood and adulthood; and whether this association remains after controlling by other variables.
Methods
In this study, the 1958 birth cohort study (British longitudinal study) is undertaken. Five waves are used for the analyses (age ranged between 11 to 50 years old). Logistic regression model was fitted for each wave separately. Unadjusted and adjusted models controlling by confounding factors (e.g., socioeconomic status (SES), birth weight) are fitted. Mixed effect logistic regression models are used after pooling all waves together to measure the correlation between repeated measurements of diagnosis asthma for the same participants during the 50 years and potentially variation among waves. Stratified analysis by sex, accommodation type and breastfeeding are also examined. Missing data and values are removed.
Results
An unadjusted and three adjusted logistic regression models are fitted. A positive significant association between mothers’ smoke prior to pregnancy and developing asthma is reported in all age groups(waves). The highest probability of asthma was at age 33 and 50 with OR 1.27; 95% confidence interval 1.16:1.28, and OR 1.33 with 95% confidence interval 1.15:1.52, respectively. After pooling all waves, the positive association remains by using the mixed logistic effect models. A female sample, council rent and no breastfeeding groups reported the highest risk factors of developing asthma compared to other groups.
Conclusion
There is a positive association between mothers’ smoking prior to pregnancy and developing asthma in childhood and adulthood. |
Keywords and phrases: longitudinal data, asthma, mothers smoke prior to pregnancy, 1958 birth cohort study.
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