The Bayesian approach under uniform prior is employed in this paper to derive the prediction distribution for multiple regression model with multivariate Student-t error distribution. Conditional on a set of realized responses, a single and a set of future responses have a univariate and multivariate Student-t distributions, respectively, whose degrees of freedom depend on the size of the realized sample and the dimension of the regression parameters’ vector but do not depend on the degrees of freedom of the error distribution. Results are identical to those obtained under normal error distribution by a range of statistical approaches such as the structural distribution, structural relations and classical methods. This indicates not only the inference robustness with respect to departures from normal error to multivariate Student-t error distributions, but also indicates that the Bayesian approach with uniform prior is competitive with other statistical methods in the derivation of prediction distribution.